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Workers clear the rubble of a building that was destroyed by an Israeli airstrike on Saturday, that housed The Associated Press, broadcaster Al-Jazeera and other media outlets, in Gaza City, Sunday, May 16, 2021. (AP Photo/Adel Hana)

Israeli airstrikes on Gaza City flattened three buildings and killed at least 26 people Sunday, medics said, making it the deadliest single attack since heavy fighting broke out between Israel and the territory’s militant Hamas rulers nearly a week ago.

The Gaza Health Ministry said 10 women and eight children were among those killed, with another 50 people wounded in the attack. A rescuer could be seen shouting into a hole in the rubble. “Can you hear me?” he called out. “Are you OK?” Minutes later, first responders managed to pull a survivor out and carried him off on an orange stretcher.

Earlier, the Israeli military said it destroyed the home of Gaza’s top Hamas leader, Yahiyeh Sinwar, in a separate strike in the southern town of Khan Younis. It was the third such attack in the last two days on the homes of senior Hamas leaders, who have gone underground.

Israel appears to have stepped up strikes in recent days to inflict as much damage as possible on Hamas as international mediators try to broker a cease-fire. But targeting the group’s leaders could hinder those efforts. A U.S. diplomat is in the region to try to de-escalate tensions, and the U.N. Security Council is set to meet Sunday.

Casualties

At least 181 Palestinians have been killed in Gaza, including 52 children and 31 women, with 1,225 wounded. Eight Israelis have been killed, including a 5-year-old boy and a soldier.

The military said Sunday it struck Sinwar’s home and that of his brother Muhammad, another senior Hamas member. On Saturday it destroyed the home of Khalil al-Hayeh, a senior figure in Hamas’ political branch.

Hamas’ upper echelon has gone into hiding in Gaza, and it is unlikely any were at home at the time of the strikes. Hamas’ top leader, Ismail Haniyeh, divides his time between Turkey and Qatar, both of which provide political support to the group.

Hamas and the Islamic Jihad militant group have acknowledged 20 fighters killed since the fighting broke out Monday. Israel says the real number is far higher and has released the names and photos of two dozen alleged operatives it says were “eliminated.”

An Egyptian diplomat said Israel’s targeting of Hamas political leaders would complicate cease-fire efforts. The diplomat, who spoke on condition of anonymity to discuss the closed-door negotiations, said Cairo is working to broker an end to the fighting. A U.S. diplomat has also been dispatched to the region and the U.N. Security Council is set to meet Sunday.

The Egyptian diplomat said the destruction of Hamas’ rocket capabilities would require a ground invasion that would “inflame the whole region.” Egypt, which made peace with Israel decades ago, has threatened to “suspend” cooperation in various fields, the official said, without elaborating.

Hamas and other militant groups have fired some 2,900 rockets into Israel. The military said 450 of the rockets had fallen short or misfired, while Israeli air defenses intercepted 1,150.